Cargando…

Genetic analysis of the human microglia transcriptome across brain regions, aging and disease pathologies

Microglia have emerged as important players in brain aging and pathology. To understand how genetic risk for neurological and psychiatric disorders is related to microglial function, large transcriptome studies are essential. Here, we describe the transcriptome analysis of 255 primary human microgli...

Descripción completa

Detalles Bibliográficos
Autores principales:	de Paiva Lopes, Katia, Snijders, Gijsje J. L., Humphrey, Jack, Allan, Amanda, Sneeboer, Marjolein, Navarro, Elisa, Schilder, Brian M., Vialle, Ricardo A., Parks, Madison, Missall, Roy, van Zuiden, Welmoed, Gigase, Frederieke, Kübler, Raphael, van Berlekom, Amber Berdenis, Hicks, Emily M., Bӧttcher, Chotima, Priller, Josef, Kahn, René S., de Witte, Lot D., Raj, Towfique
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245609/ https://www.ncbi.nlm.nih.gov/pubmed/34992268 http://dx.doi.org/10.1038/s41588-021-00976-y

Ejemplares similares

A loss of mature microglial markers without immune activation in schizophrenia
por: Snijders, Gijsje J. L. J., et al.
Publicado: (2021)

Single-cell mass cytometry of microglia in major depressive disorder reveals a non-inflammatory phenotype with increased homeostatic marker expression
por: Böttcher, Chotima, et al.
Publicado: (2020)

Microglia in post-mortem brain tissue of patients with bipolar disorder are not immune activated
por: Sneeboer, Marjolein A. M., et al.
Publicado: (2019)

Synapse Pathology in Schizophrenia: A Meta-analysis of Postsynaptic Elements in Postmortem Brain Studies
por: Berdenis van Berlekom, Amber, et al.
Publicado: (2020)

Human microglial models to study HIV infection and neuropathogenesis: a literature overview and comparative analyses
por: Gumbs, Stephanie B. H., et al.
Publicado: (2022)

Characterization of HIV-1 Infection in Microglia-Containing Human Cerebral Organoids
por: Gumbs, Stephanie B. H., et al.
Publicado: (2022)

Exposure to the Amino Acids Histidine, Lysine, and Threonine Reduces mTOR Activity and Affects Neurodevelopment in a Human Cerebral Organoid Model
por: Berdenis van Berlekom, Amber, et al.
Publicado: (2022)

Microglia innately develop within cerebral organoids
por: Ormel, Paul R., et al.
Publicado: (2018)

Tensor decomposition of stimulated monocyte and macrophage gene expression profiles identifies neurodegenerative disease-specific trans-eQTLs
por: Ramdhani, Satesh, et al.
Publicado: (2020)

Fine-mapping of Parkinson’s disease susceptibility loci identifies putative causal variants
por: Schilder, Brian M, et al.
Publicado: (2021)

The association between antibodies to neurotropic pathogens and bipolar disorder: A study in the Dutch Bipolar (DB) Cohort and meta-analysis
por: Snijders, Gijsje J. L. J., et al.
Publicado: (2019)

Effects of severe acute respiratory syndrome coronavirus 2 infection on obstetric outcomes: Results from a prospective cohort in the Netherlands
por: Gigase, Frederieke A. J., et al.
Publicado: (2022)

Chemo-Enzymatic Synthesis of Perfluoroalkyl-Functionalized Dendronized Polymers as Cyto-Compatible Nanocarriers for Drug Delivery Applications
por: Parshad, Badri, et al.
Publicado: (2016)

Maternal mortality in the Gaza strip: a look at causes and solutions
por: Bӧttcher, Bettina, et al.
Publicado: (2018)

Targeting Myeloid Cells to the Brain Using Non-Myeloablative Conditioning
por: Böttcher, Chotima, et al.
Publicado: (2013)

The use and limitations of single‐cell mass cytometry for studying human microglia function
por: Fernández‐Zapata, Camila, et al.
Publicado: (2020)

Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer’s disease
por: Guttikonda, Sudha R., et al.
Publicado: (2021)

Phenome-wide and expression quantitative trait locus associations of coronavirus disease 2019 genetic risk loci
por: Moon, Chang Yoon, et al.
Publicado: (2021)

1,2-(13)C(2)-Glucose Tracing Approach to Assess Metabolic Alterations of Human Monocytes under Neuroinflammatory Conditions
por: Giacomello, Ginevra, et al.
Publicado: (2023)

Immune modulatory effect of a novel 4,5-dihydroxy-3,3´,4´-trimethoxybibenzyl from Dendrobium lindleyi
por: Khoonrit, Pichayatri, et al.
Publicado: (2020)

Prioritizing Parkinson’s disease genes using population-scale transcriptomic data
por: Li, Yang I., et al.
Publicado: (2019)

The influence of structural racism, pandemic stress, and SARS-CoV-2 infection during pregnancy with adverse birth outcomes
por: Janevic, Teresa, et al.
Publicado: (2022)

Phenotypic comparison of human alveolar macrophages before and after in vivo rhinovirus 16 challenge
por: de Groot, Linsey E. S., et al.
Publicado: (2021)

Integrating whole-genome sequencing with multi-omic data reveals the impact of structural variants on gene regulation in the human brain
por: Vialle, Ricardo A., et al.
Publicado: (2022)

Visual Perceptual Load Does Not Affect the Frequency Mismatch Negativity
por: Wiens, Stefan, et al.
Publicado: (2019)

Cascade and no‐repetition rules are comparable controls for the auditory frequency mismatch negativity in oddball tasks
por: Wiens, Stefan, et al.
Publicado: (2018)

Cross-sectional associations of maternal PFAS exposure on SARS-CoV-2 IgG antibody levels during pregnancy
por: Kaur, Kirtan, et al.
Publicado: (2023)

Transcriptome deregulation of peripheral monocytes and whole blood in GBA-related Parkinson’s disease
por: Riboldi, Giulietta Maria, et al.
Publicado: (2022)

Peripheral and CSF inflammatory biomarkers after COVID-19 vaccination in pregnant individuals
por: Rajasekaran, Vignesh, et al.
Publicado: (2022)

Early interventions: from e-health to neurobiology
por: Olff, Miranda, et al.
Publicado: (2015)

The prevalence of antinuclear antibodies in patients with schizophrenia spectrum disorders: results from a large cohort study
por: van Mierlo, Hans C, et al.
Publicado: (2015)

META-ANALYSES ON DOUBLE-BLIND RCTS ADDING DRUGS WITH ANTI-INFLAMMATORY PROPERTIES TO ANTIPSYCHOTIC MEDICATION
por: Sommer, Iris, et al.
Publicado: (2014)

The mediating role of externalising and healthy schema modes in the relationship between early maladaptive schemata and overt behaviours in adolescent boys with offending behaviours, and a comparison of their early schemata with those of typically developing boys
por: Schilder, Dorien L. C., et al.
Publicado: (2021)

T12. VITAMIN D STATUS AND PSYCHOTIC DISORDER: ASSOCIATIONS WITH CLINICAL VARIABLES AND RISK FACTORS
por: van der Leeuw, Christine, et al.
Publicado: (2018)

The Effectiveness of an Intervention to Promote Awareness and Reduce Online Risk Behavior in Early Adolescence
por: Schilder, Janneke D., et al.
Publicado: (2015)

Toddlers’ Language Development: The Gradual Effect of Gestational Age, Attention Capacities, and Maternal Sensitivity
por: Snijders, Vera E., et al.
Publicado: (2020)

Diffuse blistering rash with ocular involvement
por: Margulies, Shae, et al.
Publicado: (2022)

Severe chronic psychosis after allogeneic SCT from a schizophrenic sibling
por: Sommer, I E, et al.
Publicado: (2015)

Speech‐language profiles in the context of cognitive and adaptive functioning in SATB2‐associated syndrome
por: Snijders Blok, Lot, et al.
Publicado: (2021)

Ulcerative necrobiosis lipoidica in the setting of anti–tumor necrosis factor-α and hydroxychloroquine treatment for rheumatoid arthritis
por: Fehlman, Jennifer Albus, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_t4u70em2v4v44dvnolh5qj9g9k