IFT80 negatively regulates osteoclast differentiation via association with Cbl-b to disrupt TRAF6 stabilization and activation

Excess bone loss due to increased osteoclastogenesis is a significant clinical problem. Intraflagellar transport (IFT) proteins have been reported to regulate cell growth and differentiation. The role of IFT80, an IFT complex B protein, in osteoclasts (OCs) is completely unknown. Here, we demonstrat...

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Detalles Bibliográficos
Autores principales: Deepak, Vishwa, Yang, Shu-ting, Li, Ziqing, Li, Xinhua, Ng, Andrew, Xu, Ding, Li, Yi-Ping, Oursler, Merry Jo, Yang, Shuying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245634/
https://www.ncbi.nlm.nih.gov/pubmed/35733270
http://dx.doi.org/10.1073/pnas.2201490119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245634/
https://www.ncbi.nlm.nih.gov/pubmed/35733270
http://dx.doi.org/10.1073/pnas.2201490119

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