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A fine balance of hydrophobic-electrostatic communication pathways in a pH-switching protein

Allostery is the phenomenon of coupling between distal binding sites in a protein. Such coupling is at the crux of protein function and regulation in a myriad of scenarios, yet determining the molecular mechanisms of coupling networks in proteins remains a major challenge. Here, we report mechanisms...

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Detalles Bibliográficos
Autores principales: MacKenzie, Duncan W. S., Schaefer, Anna, Steckner, Julia, Leo, Christopher A., Naser, Dalia, Artikis, Efrosini, Broom, Aron, Ko, Travis, Shah, Purnank, Ney, Mikaela Q., Tran, Elisa, Smith, Martin T. J., Fuglestad, Brian, Wand, A. Joshua, Brooks, Charles L., Meiering, Elizabeth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245636/
https://www.ncbi.nlm.nih.gov/pubmed/35737838
http://dx.doi.org/10.1073/pnas.2119686119