Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation

During viral infection, sensing of viral RNA by retinoic acid–inducible gene-I–like receptors (RLRs) initiates an antiviral innate immune response, which is mediated by the mitochondrial adaptor protein VISA (virus-induced signal adaptor; also known as mitochondrial antiviral signaling protein [MAVS...

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Detalles Bibliográficos
Autores principales: Xu, Yan-Ran, Shi, Meng-Ling, Zhang, Yu, Kong, Na, Wang, Cong, Xiao, Yi-Feng, Du, Shi-Shen, Zhu, Qi-Yun, Lei, Cao-Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245648/
https://www.ncbi.nlm.nih.gov/pubmed/35733260
http://dx.doi.org/10.1073/pnas.2122805119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245648/
https://www.ncbi.nlm.nih.gov/pubmed/35733260
http://dx.doi.org/10.1073/pnas.2122805119

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