Cargando…
Aging can transform single-component protein condensates into multiphase architectures
Phase-separated biomolecular condensates that contain multiple coexisting phases are widespread in vitro and in cells. Multiphase condensates emerge readily within multicomponent mixtures of biomolecules (e.g., proteins and nucleic acids) when the different components present sufficient physicochemi...
Autores principales: | Garaizar, Adiran, Espinosa, Jorge R., Joseph, Jerelle A., Krainer, Georg, Shen, Yi, Knowles, Tuomas P.J., Collepardo-Guevara, Rosana |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245653/ https://www.ncbi.nlm.nih.gov/pubmed/35727989 http://dx.doi.org/10.1073/pnas.2119800119 |
Ejemplares similares
-
Kinetic interplay between droplet maturation and coalescence modulates shape of aged protein condensates
por: Garaizar, Adiran, et al.
Publicado: (2022) -
Thermodynamic origins of two-component multiphase condensates of proteins
por: Chew, Pin Yu, et al.
Publicado: (2023) -
Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it
por: Tejedor, Andres R., et al.
Publicado: (2022) -
Valency and Binding Affinity Variations Can Regulate the Multilayered Organization of Protein Condensates with Many Components
por: Sanchez-Burgos, Ignacio, et al.
Publicado: (2021) -
Nucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions
por: Farr, Stephen E., et al.
Publicado: (2021)