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Affinity of disordered protein complexes is modulated by entropy–energy reinforcement

The association between two intrinsically disordered proteins (IDPs) may produce a fuzzy complex characterized by a high binding affinity, similar to that found in the ultrastable complexes formed between two well-structured proteins. Here, using coarse-grained simulations, we quantified the biophys...

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Detalles Bibliográficos
Autores principales: Hazra, Milan Kumar, Levy, Yaakov
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245678/
https://www.ncbi.nlm.nih.gov/pubmed/35727975
http://dx.doi.org/10.1073/pnas.2120456119