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Affinity of disordered protein complexes is modulated by entropy–energy reinforcement
The association between two intrinsically disordered proteins (IDPs) may produce a fuzzy complex characterized by a high binding affinity, similar to that found in the ultrastable complexes formed between two well-structured proteins. Here, using coarse-grained simulations, we quantified the biophys...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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National Academy of Sciences
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245678/ https://www.ncbi.nlm.nih.gov/pubmed/35727975 http://dx.doi.org/10.1073/pnas.2120456119 |