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Tas2R activation relaxes airway smooth muscle by release of Gα(t) targeting on AChR signaling

Both chronic obstructive pulmonary disease (COPD) and asthma are severe respiratory diseases. Bitter receptor–mediated bronchodilation is a potential therapy for asthma, but the mechanism underlying the agonistic relaxation of airway smooth muscle (ASM) is not well defined. By exploring the ASM rela...

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Detalles Bibliográficos
Autores principales:	Zhou, Yu-Wei, Sun, Jie, Wang, Ye, Chen, Cai-Ping, Tao, Tao, Ma, Ming, Chen, Xin, Zhang, Xue-Na, Yang, Li-Yuan, Zhang, Zhong-Liang, Li, Ye-Qiong, Jiang, Zhi-Hui, Qiu, Tian-Tian, Wang, Han, Pan, Yang, Zhang, Jian, Chen, Hua-Qun, Wang, Pei, Zhu, Min-Sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245679/ https://www.ncbi.nlm.nih.gov/pubmed/35737832 http://dx.doi.org/10.1073/pnas.2121513119

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