Retromer dysfunction in amyotrophic lateral sclerosis

Retromer is a heteropentameric complex that plays a specialized role in endosomal protein sorting and trafficking. Here, we report a reduction in the retromer proteins—vacuolar protein sorting 35 (VPS35), VPS26A, and VPS29—in patients with amyotrophic lateral sclerosis (ALS) and in the ALS model pro...

Descripción completa

Detalles Bibliográficos
Autores principales: Pérez-Torres, Eduardo J., Utkina-Sosunova, Irina, Mishra, Vartika, Barbuti, Peter, De Planell-Saguer, Mariangels, Dermentzaki, Georgia, Geiger, Heather, Basile, Anna O., Robine, Nicolas, Fagegaltier, Delphine, Politi, Kristin A., Rinchetti, Paola, Jackson-Lewis, Vernice, Harms, Matthew, Phatnani, Hemali, Lotti, Francesco, Przedborski, Serge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245686/
https://www.ncbi.nlm.nih.gov/pubmed/35749364
http://dx.doi.org/10.1073/pnas.2118755119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245686/
https://www.ncbi.nlm.nih.gov/pubmed/35749364
http://dx.doi.org/10.1073/pnas.2118755119

Ejemplares similares