N(1)-methylpseudouridine-incorporated mRNA enhances exogenous protein expression and suppresses immunogenicity in primary human fibroblast-like synoviocytes

Studies conducted using murine arthritis models have indicated that the use of in vitro-transcribed messenger RNA (IVT mRNA) is an effective therapeutic approach for joint diseases. However, the use of IVT mRNA in human synovial cells has not been widely studied. Recently, the outbreak of the novel...

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Detalles Bibliográficos
Autores principales: Mokuda, Sho, Watanabe, Hirofumi, Kohno, Hiroki, Ishitoku, Michinori, Araki, Kei, Hirata, Shintaro, Sugiyama, Eiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245880/
https://www.ncbi.nlm.nih.gov/pubmed/35791402
http://dx.doi.org/10.1007/s10616-022-00540-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245880/
https://www.ncbi.nlm.nih.gov/pubmed/35791402
http://dx.doi.org/10.1007/s10616-022-00540-4

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