Mannose-6-phosphate glycan for lysosomal targeting: various applications from enzyme replacement therapy to lysosome-targeting chimeras

A lysosome, an acidic membrane-bound organelle, contains hydrolytic enzymes to digest macromolecules for recycling. Many lysosomal enzymes (LEs) traffic to the lysosome through the mannose-6-phosphate (M6P)-dependent pathway. Some mannose residues of high-mannose type N-glycans on LEs can be phospho...

Descripción completa

Detalles Bibliográficos
Autores principales: Seo, Jinho, Oh, Doo-Byoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Physiology & Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246025/
https://www.ncbi.nlm.nih.gov/pubmed/35784393
http://dx.doi.org/10.1080/19768354.2022.2079719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246025/
https://www.ncbi.nlm.nih.gov/pubmed/35784393
http://dx.doi.org/10.1080/19768354.2022.2079719

Ejemplares similares