Metabolic and epigenetic dysfunctions underlie the arrest of in vitro fertilized human embryos in a senescent-like state

Around 60% of in vitro fertilized (IVF) human embryos irreversibly arrest before compaction between the 3- to 8-cell stage, posing a significant clinical problem. The mechanisms behind this arrest are unclear. Here, we show that the arrested embryos enter a senescent-like state, marked by cell cycle...

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Detalles Bibliográficos
Autores principales: Yang, Yang, Shi, Liyang, Fu, Xiuling, Ma, Gang, Yang, Zhongzhou, Li, Yuhao, Zhou, Yibin, Yuan, Lihua, Xia, Ye, Zhong, Xiufang, Yin, Ping, Sun, Li, Zhang, Wuwen, Babarinde, Isaac A., Wang, Yongjun, Zhao, Xiaoyang, Hutchins, Andrew P., Tong, Guoqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246109/
https://www.ncbi.nlm.nih.gov/pubmed/35771762
http://dx.doi.org/10.1371/journal.pbio.3001682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246109/
https://www.ncbi.nlm.nih.gov/pubmed/35771762
http://dx.doi.org/10.1371/journal.pbio.3001682

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