Structure-based optimization of type III indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

The haem enzyme indoleamine 2,3-dioxygenase 1 (IDO1) catalyses the rate-limiting step in the kynurenine pathway of tryptophan metabolism and plays an essential role in immunity, neuronal function, and ageing. Expression of IDO1 in cancer cells results in the suppression of an immune response, and th...

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Detalles Bibliográficos
Autores principales: Röhrig, Ute F., Majjigapu, Somi Reddy, Vogel, Pierre, Reynaud, Aline, Pojer, Florence, Dilek, Nahzli, Reichenbach, Patrick, Ascenção, Kelly, Irving, Melita, Coukos, George, Michielin, Olivier, Zoete, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246256/
https://www.ncbi.nlm.nih.gov/pubmed/35758198
http://dx.doi.org/10.1080/14756366.2022.2089665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246256/
https://www.ncbi.nlm.nih.gov/pubmed/35758198
http://dx.doi.org/10.1080/14756366.2022.2089665

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