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Analysis of estrogen-regulated enhancer RNAs identifies a functional motif required for enhancer assembly and gene expression
To better understand the functions of non-coding enhancer RNAs (eRNAs), we annotated the estrogen-regulated eRNA transcriptome in estrogen receptor α (ERα)-positive breast cancer cells using PRO-cap and RNA sequencing. We then cloned a subset of the eRNAs identified, fused them to single guide RNAs,...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246336/ https://www.ncbi.nlm.nih.gov/pubmed/35705040 http://dx.doi.org/10.1016/j.celrep.2022.110944 |