Endogenous glutamine is rate-limiting for anti-CD3 and anti-CD28 induced CD4(+) T-cell proliferation and glycolytic activity under hypoxia and normoxia

To meet the demand for energy and biomass, T lymphocytes (T cells) activated to proliferation and clonal expansion, require uptake and metabolism of glucose (Gluc) and the amino acid (AA) glutamine (Gln). Whereas exogenous Gln is converted to glutamate (Glu) by glutaminase (GLS), Gln is also synthes...

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Detalles Bibliográficos
Autores principales: Wik, Jonas A., Chowdhury, Azazul, Kolan, Shrikant, Bastani, Nasser E., Li, Gaoyang, Alam, Kazi, Grimolizzi, Franco, Skålhegg, Bjørn S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246347/
https://www.ncbi.nlm.nih.gov/pubmed/35695514
http://dx.doi.org/10.1042/BCJ20220144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246347/
https://www.ncbi.nlm.nih.gov/pubmed/35695514
http://dx.doi.org/10.1042/BCJ20220144

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