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Endogenous glutamine is rate-limiting for anti-CD3 and anti-CD28 induced CD4(+) T-cell proliferation and glycolytic activity under hypoxia and normoxia
To meet the demand for energy and biomass, T lymphocytes (T cells) activated to proliferation and clonal expansion, require uptake and metabolism of glucose (Gluc) and the amino acid (AA) glutamine (Gln). Whereas exogenous Gln is converted to glutamate (Glu) by glutaminase (GLS), Gln is also synthes...
Autores principales: | Wik, Jonas A., Chowdhury, Azazul, Kolan, Shrikant, Bastani, Nasser E., Li, Gaoyang, Alam, Kazi, Grimolizzi, Franco, Skålhegg, Bjørn S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246347/ https://www.ncbi.nlm.nih.gov/pubmed/35695514 http://dx.doi.org/10.1042/BCJ20220144 |
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