Donor T cell DNMT3a regulates alloreactivity in mouse models of hematopoietic stem cell transplantation

DNA methyltransferase 3a (DNMT3a) is an important part of the epigenetic machinery that stabilizes patterns of activated T cell responses. We hypothesized that donor T cell DNMT3a regulates alloreactivity after allogeneic blood and marrow transplantation (allo-BMT). T cell conditional Dnmt3a KO mice...

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Detalles Bibliográficos
Autores principales: Ktena, Yiouli P., Koldobskiy, Michael A., Barbato, Michael I., Fu, Han-Hsuan, Luznik, Leo, Llosa, Nicolas J., Haile, Azeb, Klein, Orly R., Liu, Chen, Gamper, Christopher J., Cooke, Kenneth R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246380/
https://www.ncbi.nlm.nih.gov/pubmed/35608905
http://dx.doi.org/10.1172/JCI158047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246380/
https://www.ncbi.nlm.nih.gov/pubmed/35608905
http://dx.doi.org/10.1172/JCI158047

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