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Erythroid lineage Jak2(V617F) expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis
Elevated hematocrit is associated with cardiovascular risk; however, the causality and mechanisms are unclear. The JAK2(V617F) (Jak2(VF)) mutation increases cardiovascular risk in myeloproliferative disorders and in clonal hematopoiesis. Jak2(VF) mice with elevated WBCs, platelets, and RBCs display...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246386/ https://www.ncbi.nlm.nih.gov/pubmed/35587375 http://dx.doi.org/10.1172/JCI155724 |