Erythroid lineage Jak2(V617F) expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis

Elevated hematocrit is associated with cardiovascular risk; however, the causality and mechanisms are unclear. The JAK2(V617F) (Jak2(VF)) mutation increases cardiovascular risk in myeloproliferative disorders and in clonal hematopoiesis. Jak2(VF) mice with elevated WBCs, platelets, and RBCs display...

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Detalles Bibliográficos
Autores principales: Liu, Wenli, Östberg, Nataliya, Yalcinkaya, Mustafa, Dou, Huijuan, Endo-Umeda, Kaori, Tang, Yang, Hou, Xintong, Xiao, Tong, Fidler, Trevor P., Abramowicz, Sandra, Yang, Yong-Guang, Soehnlein, Oliver, Tall, Alan R., Wang, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246386/
https://www.ncbi.nlm.nih.gov/pubmed/35587375
http://dx.doi.org/10.1172/JCI155724

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