Cargando…

High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3

INTRODUCTION: The organic cation transporter 3 (OCT3, SLC22A3) is ubiquitously expressed and interacts with a wide array of compounds including endogenous molecules, environmental toxins and prescription drugs. Understudied as a determinant of pharmacokinetics and pharmacodynamics, OCT3 has the pote...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Eugene C., Matsson, Pär, Azimi, Mina, Zhou, Xujia, Handin, Niklas, Yee, Sook Wah, Artursson, Per, Giacomini, Kathleen M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246766/ https://www.ncbi.nlm.nih.gov/pubmed/35089508 http://dx.doi.org/10.1007/s11095-022-03171-8

Ejemplares similares

A High-Throughput Cell-Based Method to Predict the Unbound Drug Fraction in the Brain
por: Mateus, André, et al.
Publicado: (2014)

Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue
por: Song, Wenxin, et al.
Publicado: (2019)

Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content
por: Liang, Xiaomin, et al.
Publicado: (2018)

A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (f(u,cell))
por: Treyer, Andrea, et al.
Publicado: (2019)

Discovery of Regulatory Elements in Human ATP-Binding Cassette Transporters through Expression Quantitative Trait Mapping
por: Matsson, Pär, et al.
Publicado: (2011)

Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates
por: Yee, Sook Wah, et al.
Publicado: (2023)

Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates
por: Yee, Sook Wah, et al.
Publicado: (2023)

Genetic and Epigenetic Regulation of the Organic Cation Transporter 3, SLC22A3
por: Chen, Ligong, et al.
Publicado: (2012)

Conditions for maintenance of hepatocyte differentiation and function in 3D cultures
por: Handin, Niklas, et al.
Publicado: (2021)

Intracellular drug bioavailability: a new predictor of system dependent drug disposition
por: Mateus, André, et al.
Publicado: (2017)

The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics
por: Yee, Sook Wah, et al.
Publicado: (2023)

Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes
por: Wegler, Christine, et al.
Publicado: (2021)

Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells
por: Kundu, Snehangshu, et al.
Publicado: (2018)

Loss of organic cation transporter 3 (Oct3) leads to enhanced proliferation and hepatocarcinogenesis
por: Vollmar, Johanna, et al.
Publicado: (2017)

New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium
por: Giacomini, Kathleen M., et al.
Publicado: (2022)

Early Identification of Clinically Relevant Drug Interactions With the Human Bile Salt Export Pump (BSEP/ABCB11)
por: Pedersen, Jenny M., et al.
Publicado: (2013)

Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis
por: Kundu, Snehangshu, et al.
Publicado: (2021)

Role of Organic Cation Transporter 1, OCT1 in the Pharmacokinetics and Toxicity of cis-Diammine(pyridine)chloroplatinum(II) and Oxaliplatin in Mice
por: Li, Shuanglian, et al.
Publicado: (2010)

Downregulation of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) in human hepatocellular carcinoma and their prognostic significance
por: Heise, Michael, et al.
Publicado: (2012)

Proteome deconvolution of liver biopsies reveals hepatic cell composition as an important marker of fibrosis
por: Handin, Niklas, et al.
Publicado: (2023)

The Impacts of Slc19a3 Deletion and Intestinal SLC19A3 Insertion on Thiamine Distribution and Brain Metabolism in the Mouse
por: Wen, Anita, et al.
Publicado: (2023)

Targeted disruption of organic cation transporter 3 (Oct3) ameliorates ischemic brain damage through modulating histamine and regulatory T cells
por: Zhu, Pengxiang, et al.
Publicado: (2012)

Computational modeling to predict the functions and impact of drug transporters
por: Matsson, Pär, et al.
Publicado: (2015)

OCT and ERG Techniques in High-Throughput Phenotyping of Mouse Vision
por: Lindovsky, Jiri, et al.
Publicado: (2023)

Cloning and Functional Characterization of Dog OCT1 and OCT2: Another Step in Exploring Species Differences in Organic Cation Transporters
por: Meyer, Marleen Julia, et al.
Publicado: (2022)

Proton Pump Inhibitors Inhibit Metformin Uptake by Organic Cation Transporters (OCTs)
por: Nies, Anne T., et al.
Publicado: (2011)

Role of Human Organic Cation Transporter 1 (hOCT1) Polymorphisms in Lamivudine (3TC) Uptake and Drug-Drug Interactions
por: Arimany-Nardi, Cristina, et al.
Publicado: (2016)

Generation of RNAi Libraries for High-Throughput Screens
por: Clark, Julie, et al.
Publicado: (2006)

Efavirenz reduces renal excretion of lamivudine in rats by inhibiting organic cation transporters (OCT, Oct) and multidrug and toxin extrusion proteins (MATE, Mate)
por: Ceckova, Martina, et al.
Publicado: (2018)

True logarithmic amplification of frequency clock in SS-OCT for calibration
por: Liu, Bin, et al.
Publicado: (2011)

Profiling Solute Carrier Transporters in the Human Blood-Brain Barrier
por: Geier, Ethan G., et al.
Publicado: (2013)

Library 3.0: intelligent libraries and apomediation
por: Kwanya, Tom, et al.
Publicado: (2015)

Association between the synonymous variant organic cation transporter 3 (OCT3)-1233G>A and the glycemic response following metformin therapy in patients with type 2 diabetes
por: Hosseyni-Talei, Seyyedeh Raheleh, et al.
Publicado: (2017)

Influence of Cation Transporters (OCTs and MATEs) on the Renal and Hepatobiliary Disposition of [(11)C]Metoclopramide in Mice
por: Hernández-Lozano, Irene, et al.
Publicado: (2021)

Characterization of ligand-induced thermal stability of the human organic cation transporter 2 (OCT2)
por: Maane, Max, et al.
Publicado: (2023)

Increased Throughput by Parallelization of Library Preparation for Massive Sequencing
por: Lundin, Sverker, et al.
Publicado: (2010)

Large Scale Library Generation for High Throughput Sequencing
por: Borgström, Erik, et al.
Publicado: (2011)

Fusion of 3D QCA and IVUS/OCT
por: Tu, Shengxian, et al.
Publicado: (2011)

EN Newsletter Issue #3 - Oct 2021
por: Jensen, Lars
Publicado: (2021)

Library of Cationic Organic Dyes for Visible-Light-Driven Photoredox Transformations
por: Pitre, Spencer P., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_8fhn7dujq1grf0cb9n8sftvgl0