Drug Distribution in Brain and Cerebrospinal Fluids in Relation to IC(50) Values in Aging and Alzheimer’s Disease, Using the Physiologically Based LeiCNS-PK3.0 Model

BACKGROUND: Very little knowledge exists on the impact of Alzheimer’s disease on the CNS target site pharmacokinetics (PK). AIM: To predict the CNS PK of cognitively healthy young and elderly and of Alzheimer’s patients using the physiologically based LeiCNS-PK3.0 model. METHODS: LeiCNS-PK3.0 was us...

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Detalles Bibliográficos
Autores principales: Saleh, Mohammed A. A., Bloemberg, Julia S., Elassaiss-Schaap, Jeroen, de Lange, Elizabeth C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246802/
https://www.ncbi.nlm.nih.gov/pubmed/35606598
http://dx.doi.org/10.1007/s11095-022-03281-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246802/
https://www.ncbi.nlm.nih.gov/pubmed/35606598
http://dx.doi.org/10.1007/s11095-022-03281-3

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