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Drug Distribution in Brain and Cerebrospinal Fluids in Relation to IC(50) Values in Aging and Alzheimer’s Disease, Using the Physiologically Based LeiCNS-PK3.0 Model
BACKGROUND: Very little knowledge exists on the impact of Alzheimer’s disease on the CNS target site pharmacokinetics (PK). AIM: To predict the CNS PK of cognitively healthy young and elderly and of Alzheimer’s patients using the physiologically based LeiCNS-PK3.0 model. METHODS: LeiCNS-PK3.0 was us...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer US
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246802/ https://www.ncbi.nlm.nih.gov/pubmed/35606598 http://dx.doi.org/10.1007/s11095-022-03281-3 |