Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus

Membrane protein efflux pumps confer antibiotic resistance by extruding structurally distinct compounds and lowering their intracellular concentration. Yet there are no clinically approved drugs to inhibit efflux pumps, which would potentiate the efficacy of existing antibiotics rendered ineffective...

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Detalles Bibliográficos
Autores principales: Brawley, Douglas N., Sauer, David B., Li, Jianping, Zheng, Xuhui, Koide, Akiko, Jedhe, Ganesh S., Suwatthee, Tiffany, Song, Jinmei, Liu, Zheng, Arora, Paramjit S., Koide, Shohei, Torres, Victor J., Wang, Da-Neng, Traaseth, Nathaniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246859/
https://www.ncbi.nlm.nih.gov/pubmed/35361990
http://dx.doi.org/10.1038/s41589-022-00994-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246859/
https://www.ncbi.nlm.nih.gov/pubmed/35361990
http://dx.doi.org/10.1038/s41589-022-00994-9

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