Scalable Biological Signal Recording in Mammalian Cells Using Cas12a Base Editors

Biological signal recording enables the study of molecular inputs experienced throughout cellular history. However, current methods are limited in their ability to scale up beyond a single signal in mammalian contexts. Here, we develop an approach using a hyper-efficient dCas12a base editor for mult...

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Detalles Bibliográficos
Autores principales: Kempton, Hannah R, Love, Kasey S, Guo, Lucie Y, Qi, Lei S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246900/
https://www.ncbi.nlm.nih.gov/pubmed/35637351
http://dx.doi.org/10.1038/s41589-022-01034-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246900/
https://www.ncbi.nlm.nih.gov/pubmed/35637351
http://dx.doi.org/10.1038/s41589-022-01034-2

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