Riluzole regulates pancreatic cancer cell metabolism by suppressing the Wnt-β-catenin pathway

Most cancer cells rely on aerobic glycolysis to support uncontrolled proliferation and evade apoptosis. However, pancreatic cancer cells switch to glutamine metabolism to survive under hypoxic conditions. Activation of the Wnt/β-catenin pathway induces aerobic glycolysis by activating enzymes requir...

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Detalles Bibliográficos
Autores principales: Roy, Sanjit K., Ma, Yiming, Lam, Bao Q., Shrivastava, Anju, Srivastav, Sudesh, Shankar, Sharmila, Srivastava, Rakesh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246955/
https://www.ncbi.nlm.nih.gov/pubmed/35773307
http://dx.doi.org/10.1038/s41598-022-13472-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246955/
https://www.ncbi.nlm.nih.gov/pubmed/35773307
http://dx.doi.org/10.1038/s41598-022-13472-y

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