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Radial pair correlation of molecular brightness fluctuations maps protein diffusion as a function of oligomeric state within live-cell nuclear architecture

Nuclear proteins can modulate their DNA binding activity and the exploration volume available during DNA target search by self-associating into higher-order oligomers. Directly tracking this process in the nucleoplasm of a living cell is, however, a complex task. Thus, here we present a microscopy m...

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Detalles Bibliográficos
Autores principales: Solano, Ashleigh, Lou, Jieqiong, Scipioni, Lorenzo, Gratton, Enrico, Hinde, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247470/
https://www.ncbi.nlm.nih.gov/pubmed/35490296
http://dx.doi.org/10.1016/j.bpj.2022.04.030