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Cancer cell-autonomous overactivation of PARP1 compromises immunosurveillance in non-small cell lung cancer

BACKGROUND: High activity of poly(ADP-ribose) polymerase-1 (PARP1) in non-small cell lung cancer (NSCLC) cells leads to an increase in immunohistochemically detectable PAR, correlating with poor prognosis in patients with NSCLC, as well as reduced tumor infiltration by cytotoxic T lymphocytes (CTLs)...

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Detalles Bibliográficos
Autores principales: Juncheng, Pan, Joseph, Adrien, Lafarge, Antoine, Martins, Isabelle, Obrist, Florine, Pol, Jonathan, Saavedra, Ester, Li, Sijing, Sauvat, Allan, Cerrato, Giulia, Lévesque, Sarah, Leduc, Marion, Kepp, Oliver, Durand, Sylvère, Aprahamian, Fanny, Nirmalathansan, Nitharsshini, Michels, Judith, Kroemer, Guido, Castedo, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247697/
https://www.ncbi.nlm.nih.gov/pubmed/35772809
http://dx.doi.org/10.1136/jitc-2021-004280