Accessing Diverse Pyridine-Based Macrocyclic Peptides by a Two-Site Recognition Pathway

[Image: see text] Macrocyclic peptides are sought-after molecular scaffolds for drug discovery, and new methods to access diverse libraries are of increasing interest. Here, we report the enzymatic synthesis of pyridine-based macrocyclic peptides (pyritides) from linear precursor peptides. Pyritides...

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Detalles Bibliográficos
Autores principales: Nguyen, Dinh T., Le, Tung T., Rice, Andrew J., Hudson, Graham A., van der Donk, Wilfred A., Mitchell, Douglas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247985/
https://www.ncbi.nlm.nih.gov/pubmed/35713415
http://dx.doi.org/10.1021/jacs.2c02824

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247985/
https://www.ncbi.nlm.nih.gov/pubmed/35713415
http://dx.doi.org/10.1021/jacs.2c02824

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