Symmetric and Asymmetric Receptor Conformation Continuum induced by a Novel Insulin

Cone snail venoms contain a wide variety of bioactive peptides, including insulin-like molecules with distinct structural features, binding modes, and biochemical properties. Here, we report a fully active humanized cone snail venom insulin with an elongated A chain and a truncated B chain, and use...

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Detalles Bibliográficos
Autores principales: Xiong, Xiaochun, Blakely, Alan, Kim, Jin Hwan, Menting, John G., Schäfer, Ingmar B., Schubert, Heidi L., Agrawal, Rahul, Gutmann, Theresia, Delaine, Carlie, Zhang, Yi Wolf, Artik, Gizem Olay, Merriman, Allanah, Eckert, Debbie, Lawrence, Michael C., Coskun, Ünal, Fisher, Simon J., Forbes, Briony E., Safavi-Hemami, Helena, Hill, Christopher P., Chou, Danny Hung-Chieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248236/
https://www.ncbi.nlm.nih.gov/pubmed/35289328
http://dx.doi.org/10.1038/s41589-022-00981-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248236/
https://www.ncbi.nlm.nih.gov/pubmed/35289328
http://dx.doi.org/10.1038/s41589-022-00981-0

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