The Combination of the CDK4/6 Inhibitor, Palbociclib, With the Vitamin D(3) Analog, Inecalcitol, Has Potent In Vitro and In Vivo Anticancer Effects in Hormone-Sensitive Breast Cancer, But Has a More Limited Effect in Triple-Negative Breast Cancer

Active vitamin D(3), 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], and its synthetically derived analogs possess potent anticancer properties. In breast cancer (BC) cells, 1,25(OH)(2)D(3) blocks cell proliferation and induces apoptosis through different cell-type specific mechanisms. In this study,...

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Detalles Bibliográficos
Autores principales: Vanhevel, Justine, Verlinden, Lieve, Loopmans, Shauni, Doms, Stefanie, Janssens, Iris, Bevers, Sien, Stegen, Steve, Wildiers, Hans, Verstuyf, Annemieke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248359/
https://www.ncbi.nlm.nih.gov/pubmed/35784555
http://dx.doi.org/10.3389/fendo.2022.886238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248359/
https://www.ncbi.nlm.nih.gov/pubmed/35784555
http://dx.doi.org/10.3389/fendo.2022.886238

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