Surgical resection of glioblastomas induces pleiotrophin-mediated self-renewal of glioblastoma stem cells in recurrent tumors

BACKGROUND: Glioblastomas are highly resistant to therapy, and virtually all patients experience tumor recurrence after standard-of-care treatment. Surgical tumor resection is a cornerstone in glioblastoma therapy, but its impact on cellular phenotypes in the local postsurgical microenvironment has...

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Detalles Bibliográficos
Autores principales: Knudsen, Arnon Møldrup, Halle, Bo, Cédile, Oriane, Burton, Mark, Baun, Christina, Thisgaard, Helge, Anand, Atul, Hubert, Christopher, Thomassen, Mads, Michaelsen, Signe Regner, Olsen, Birgitte Brinkmann, Dahlrot, Rikke Hedegaard, Bjerkvig, Rolf, Lathia, Justin Durla, Kristensen, Bjarne Winther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248408/
https://www.ncbi.nlm.nih.gov/pubmed/34964899
http://dx.doi.org/10.1093/neuonc/noab302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248408/
https://www.ncbi.nlm.nih.gov/pubmed/34964899
http://dx.doi.org/10.1093/neuonc/noab302

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