Sclerostin Suppression Facilitates Uveal Melanoma Progression Through Activating Wnt/β-Catenin Signaling Via Binding to Membrane Receptors LRP5/LRP6

OBJECTIVE: Uveal melanoma (UM) is the most frequent primary eye cancer in adults with a 50% mortality rate. Characterizing the fundamental signaling pathways that drive UM is of importance for the development of targeted therapy. This study aims to probe the impact of sclerostin (SOST) on malignant...

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Detalles Bibliográficos
Autores principales: Wang, Hanqing, Zhao, Sidi, Liu, Yang, Sun, Fengyuan, Huang, Xiaoming, Wu, Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248439/
https://www.ncbi.nlm.nih.gov/pubmed/35785219
http://dx.doi.org/10.3389/fonc.2022.898047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248439/
https://www.ncbi.nlm.nih.gov/pubmed/35785219
http://dx.doi.org/10.3389/fonc.2022.898047

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