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Evolution of transcription factor binding through sequence variations and turnover of binding sites

Variations in noncoding regulatory sequences play a central role in evolution. Interpreting such variations, however, remains difficult even in the context of defined attributes such as transcription factor (TF) binding sites. Here, we systematically link variations in cis-regulatory sequences to TF...

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Detalles Bibliográficos
Autores principales: Krieger, Gat, Lupo, Offir, Wittkopp, Patricia, Barkai, Naama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248875/
https://www.ncbi.nlm.nih.gov/pubmed/35618416
http://dx.doi.org/10.1101/gr.276715.122