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Frequent somatic gene conversion as a mechanism for loss of heterozygosity in tumor suppressor genes
The major processes in carcinogenesis include the inactivation of tumor-suppressor genes (TSGs). Although Knudson's two-hit model requires two independent inactivating mutations, perhaps more frequently, a TSG inactivation can occur through a loss of heterozygosity (LOH) of an inactivating muta...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248884/ https://www.ncbi.nlm.nih.gov/pubmed/35618418 http://dx.doi.org/10.1101/gr.276617.122 |