Endogenous Sterol Synthesis Is Dispensable for Trypanosoma cruzi Epimastigote Growth but Not Stress Tolerance

In addition to scavenging exogenous cholesterol, the parasitic kinetoplastid Trypanosoma cruzi can endogenously synthesize sterols. Similar to fungal species, T. cruzi synthesizes ergostane type sterols and is sensitive to a class of azole inhibitors of ergosterol biosynthesis that target the enzyme...

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Detalles Bibliográficos
Autores principales: Dumoulin, Peter C., Vollrath, Joshua, Won, Madalyn M., Wang, Jennifer X., Burleigh, Barbara A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248972/
https://www.ncbi.nlm.nih.gov/pubmed/35783434
http://dx.doi.org/10.3389/fmicb.2022.937910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248972/
https://www.ncbi.nlm.nih.gov/pubmed/35783434
http://dx.doi.org/10.3389/fmicb.2022.937910

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