Cardiac glycoside-mediated turnover of Na, K-ATPases as a rational approach to reducing cell surface levels of the cellular prion protein

It is widely anticipated that a reduction of brain levels of the cellular prion protein (PrP(C)) can prolong survival in a group of neurodegenerative diseases known as prion diseases. To date, efforts to decrease steady-state PrP(C) levels by targeting this protein directly with small molecule drug-...

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Detalles Bibliográficos
Autores principales: Mehrabian, Mohadeseh, Wang, Xinzhu, Eid, Shehab, Yan, Bei Qi, Grinberg, Mark, Siegner, Murdock, Sackmann, Christopher, Sulman, Muhammad, Zhao, Wenda, Williams, Declan, Schmitt-Ulms, Gerold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249225/
https://www.ncbi.nlm.nih.gov/pubmed/35776750
http://dx.doi.org/10.1371/journal.pone.0270915

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249225/
https://www.ncbi.nlm.nih.gov/pubmed/35776750
http://dx.doi.org/10.1371/journal.pone.0270915

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