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Cardiac glycoside-mediated turnover of Na, K-ATPases as a rational approach to reducing cell surface levels of the cellular prion protein
It is widely anticipated that a reduction of brain levels of the cellular prion protein (PrP(C)) can prolong survival in a group of neurodegenerative diseases known as prion diseases. To date, efforts to decrease steady-state PrP(C) levels by targeting this protein directly with small molecule drug-...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249225/ https://www.ncbi.nlm.nih.gov/pubmed/35776750 http://dx.doi.org/10.1371/journal.pone.0270915 |