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The glucocorticoid receptor represses, whereas C/EBPβ can enhance or repress CYP26A1 transcription
Retinoic acid (RA) counters insulin’s metabolic actions. Insulin reduces liver RA biosynthesis by exporting FoxO1 from nuclei. RA induces its catabolism, catalyzed by CYP26A1. A CYP26A1 contribution to RA homeostasis with changes in energy status had not been investigated. We found that glucagon, co...
Autores principales: | Yoo, Hong Sik, Rodriguez, Adrienne, You, Dongjoo, Lee, Rebecca A., Cockrum, Michael A., Grimes, Jack A., Wang, Jen-Chywan, Kang, Sona, Napoli, Joseph L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249609/ https://www.ncbi.nlm.nih.gov/pubmed/35789854 http://dx.doi.org/10.1016/j.isci.2022.104564 |
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