A small-molecule Skp1 inhibitor elicits cell death by p53-dependent mechanism

Skp1 overexpression promotes tumor growth, whereas reduced Skp1 activity is also linked with genomic instability and neoplastic transformation. This highlights the need to gain better understanding of Skp1 biology in cancer settings. To this context, potent and cellularly active small-molecule Skp1...

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Detalles Bibliográficos
Autores principales: Hussain, Muzammal, Lu, Yongzhi, Tariq, Muqddas, Jiang, Hao, Shu, Yahai, Luo, Shuang, Zhu, Qiang, Zhang, Jiancun, Liu, Jinsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249674/
https://www.ncbi.nlm.nih.gov/pubmed/35789855
http://dx.doi.org/10.1016/j.isci.2022.104591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249674/
https://www.ncbi.nlm.nih.gov/pubmed/35789855
http://dx.doi.org/10.1016/j.isci.2022.104591

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