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DDX1 vesicles control calcium-dependent mitochondrial activity in mouse embryos

The DEAD box protein DDX1, previously associated with 3’-end RNA processing and DNA repair, forms large aggregates in the cytoplasm of early mouse embryos. Ddx1 knockout causes stalling of embryos at the 2-4 cell stages. Here, we identify a DDX1-containing membrane-bound calcium-containing organelle...

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Detalles Bibliográficos
Autores principales: Wang, Yixiong, Yasmin, Lubna, Li, Lei, Gao, Pinzhang, Xu, Xia, Sun, Xuejun, Godbout, Roseline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249788/
https://www.ncbi.nlm.nih.gov/pubmed/35778392
http://dx.doi.org/10.1038/s41467-022-31497-9