Cargando…

Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria

How bacteria sense and respond to nitrogen levels are central questions in microbial physiology. In Gram-positive bacteria, nitrogen homeostasis is controlled by an operon encoding glutamine synthetase (GS), a dodecameric machine that assimilates ammonium into glutamine, and the GlnR repressor. GlnR...

Descripción completa

Detalles Bibliográficos
Autores principales:	Travis, Brady A., Peck, Jared V., Salinas, Raul, Dopkins, Brandon, Lent, Nicholas, Nguyen, Viet D., Borgnia, Mario J., Brennan, Richard G., Schumacher, Maria A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249791/ https://www.ncbi.nlm.nih.gov/pubmed/35778410 http://dx.doi.org/10.1038/s41467-022-31573-0

Ejemplares similares

M. mazei glutamine synthetase and glutamine synthetase-GlnK1 structures reveal enzyme regulation by oligomer modulation
por: Schumacher, Maria A., et al.
Publicado: (2023)

The GlnR Regulon in Streptococcus mutans Is Differentially Regulated by GlnR and PmrA
por: Chen, Yi-Ywan M., et al.
Publicado: (2016)

The Unexpected Essentiality of glnA2 in Mycobacterium smegmatis Is Salvaged by Overexpression of the Global Nitrogen Regulator glnR, but Not by L-, D- or Iso-Glutamine
por: Rakovitsky, Nadya, et al.
Publicado: (2018)

Genome-wide mapping of GlnR-binding sites reveals the global regulatory role of GlnR in controlling the metabolism of nitrogen and carbon in Paenibacillus polymyxa WLY78
por: Wang, Tianshu, et al.
Publicado: (2023)

Genome wide analysis of the complete GlnR nitrogen-response regulon in Mycobacterium smegmatis
por: Jenkins, Victoria A, et al.
Publicado: (2013)

Comparative genome analysis of central nitrogen metabolism and its control by GlnR in the class Bacilli
por: Kormelink, Tom Groot, et al.
Publicado: (2012)

GlnR Activation Induces Peroxide Resistance in Mycobacterial Biofilms
por: Yang, Yong, et al.
Publicado: (2018)

Positive and negative regulation of transferred nif genes mediated by indigenous GlnR in Gram-positive Paenibacillus polymyxa
por: Wang, Tianshu, et al.
Publicado: (2018)

Effects of dual deletion of glnR and mtrA on expression of nitrogen metabolism genes in Streptomyces venezuelae
por: Zhu, Yanping, et al.
Publicado: (2022)

Competition between the GlnR and PhoP regulators for the glnA and amtB promoters in Streptomyces coelicolor
por: Sola-Landa, Alberto, et al.
Publicado: (2013)

Revisiting the in vivo GlnR-binding sites at the genome scale in Bacillus subtilis
por: Randazzo, Paola, et al.
Publicado: (2017)

Regulation of Nir gene in Lactobacillus plantarum WU14 mediated by GlnR
por: Qiu, Hulin, et al.
Publicado: (2022)

Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes
por: Pullan, Steven T, et al.
Publicado: (2011)

Phosphate control over nitrogen metabolism in Streptomyces coelicolor: direct and indirect negative control of glnR, glnA, glnII and amtB expression by the response regulator PhoP
por: Rodríguez-García, Antonio, et al.
Publicado: (2009)

GlnR-Mediated Regulation of Short-Chain Fatty Acid Assimilation in Mycobacterium smegmatis
por: Liu, Xin-Xin, et al.
Publicado: (2018)

Structural insights into the transcription activation mechanism of the global regulator GlnR from actinobacteria
por: Shi, Jing, et al.
Publicado: (2023)

Nitrogen Regulator GlnR Controls Redox Sensing and Lipids Anabolism by Directly Activating the whiB3 in Mycobacterium smegmatis
por: You, Di, et al.
Publicado: (2019)

Improving phytosterol biotransformation at low nitrogen levels by enhancing the methylcitrate cycle with transcriptional regulators PrpR and GlnR of Mycobacterium neoaurum
por: Zhang, Yang, et al.
Publicado: (2020)

Co-Inactivation of GlnR and CodY Regulators Impacts Pneumococcal Cell Wall Physiology
por: Johnston, Calum, et al.
Publicado: (2015)

Post-translational Serine/Threonine Phosphorylation and Lysine Acetylation: A Novel Regulatory Aspect of the Global Nitrogen Response Regulator GlnR in S. coelicolor M145
por: Amin, Rafat, et al.
Publicado: (2016)

Role of VicRKX and GlnR in pH-Dependent Regulation of the Streptococcus salivarius 57.I Urease Operon
por: Huang, Szu-Chuan, et al.
Publicado: (2016)

GlnR Dominates Rifamycin Biosynthesis by Activating the rif Cluster Genes Transcription Both Directly and Indirectly in Amycolatopsis mediterranei
por: Liu, Xinqiang, et al.
Publicado: (2020)

Mycobacterium smegmatis GlnR Regulates the Glyoxylate Cycle and the Methylcitrate Cycle on Fatty Acid Metabolism by Repressing icl Transcription
por: Qi, Nan, et al.
Publicado: (2021)

PhoP- and GlnR-mediated regulation of metK transcription and its impact upon S-adenosyl-methionine biosynthesis in Saccharopolyspora erythraea
por: Pei, Jin-Feng, et al.
Publicado: (2022)

Glutamate dehydrogenase and glutamine synthetase are regulated in response to nitrogen availability in Myocbacterium smegmatis
por: Harper, Catriona J, et al.
Publicado: (2010)

A Sensing Role of the Glutamine Synthetase in the Nitrogen Regulation Network in Fusarium fujikuroi
por: Wagner, Dominik, et al.
Publicado: (2013)

Transgenic expression of plastidic glutamine synthetase increases nitrogen uptake and yield in wheat
por: Hu, Mengyun, et al.
Publicado: (2018)

GlnR Negatively Regulates the Transcription of the Alanine Dehydrogenase Encoding Gene ald in Amycolatopsis mediterranei U32 under Nitrogen Limited Conditions via Specific Binding to Its Major Transcription Initiation Site
por: Wang, Ying, et al.
Publicado: (2014)

GlnK Facilitates the Dynamic Regulation of Bacterial Nitrogen Assimilation
por: Gosztolai, Adam, et al.
Publicado: (2017)

The glutamine synthetase gene family in Populus
por: Castro-Rodríguez, Vanessa, et al.
Publicado: (2011)

Glutamine Synthetase: Localization Dictates Outcome
por: Castegna, Alessandra, et al.
Publicado: (2018)

The Distinctive Regulation of Cyanobacterial Glutamine Synthetase
por: Bolay, Paul, et al.
Publicado: (2018)

Inactivation of Glutamine Synthetase-Coding Gene glnA Increases Susceptibility to Quinolones Through Increasing Outer Membrane Protein F in Salmonella enterica Serovar Typhi
por: Millanao, Ana R., et al.
Publicado: (2020)

The role of glutamine synthetase isozymes in enhancing nitrogen use efficiency of N-efficient winter wheat
por: Zhang, Zhiyong, et al.
Publicado: (2017)

Nitrogen Regulating the Expression and Localization of Four Glutamine Synthetase Isoforms in Wheat (Triticum aestivum L.)
por: Wei, Yihao, et al.
Publicado: (2020)

A New Perspective on the Role of Glutamine Synthetase in Nitrogen Remobilization in Wheat (Triticum aestivum L.)
por: Wei, Yihao, et al.
Publicado: (2021)

Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growth
por: Issaq, Sameer H., et al.
Publicado: (2019)

Leukemia Cells Resistant to Glutamine Deprivation Express Glutamine Synthetase Protein
por: Yücel, Burcu, et al.
Publicado: (2022)

Oligodendroglioma Cells Lack Glutamine Synthetase and Are Auxotrophic for Glutamine, but Do not Depend on Glutamine Anaplerosis for Growth
por: Chiu, Martina, et al.
Publicado: (2018)

Coregulation of glutamine synthetase1;2 (GLN1;2) and NADH-dependent glutamate synthase (GLT1) gene expression in Arabidopsis roots in response to ammonium supply
por: Kojima, Soichi, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_5a6g0prg2dvtcahqd4e2uleh14