Cargando…

Transcription factor paralogs orchestrate alternative gene regulatory networks by context-dependent cooperation with multiple cofactors

In eukaryotes, members of transcription factor families often exhibit similar DNA binding properties in vitro, yet orchestrate paralog-specific gene regulatory networks in vivo. The serially homologous first (T1) and third (T3) thoracic legs of Drosophila, which are specified by the Hox proteins Scr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Feng, Siqian, Rastogi, Chaitanya, Loker, Ryan, Glassford, William J., Tomas Rube, H., Bussemaker, Harmen J., Mann, Richard S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249852/ https://www.ncbi.nlm.nih.gov/pubmed/35778382 http://dx.doi.org/10.1038/s41467-022-31501-2

Ejemplares similares

A unified approach for quantifying and interpreting DNA shape readout by transcription factors
por: Rube, H Tomas, et al.
Publicado: (2018)

Accurate and sensitive quantification of protein-DNA binding affinity
por: Rastogi, Chaitanya, et al.
Publicado: (2018)

In vivo Hox binding specificity revealed by systematic changes to a single cis regulatory module
por: Sánchez-Higueras, Carlos, et al.
Publicado: (2019)

Prediction of protein–ligand binding affinity from sequencing data with interpretable machine learning
por: Rube, H. Tomas, et al.
Publicado: (2022)

SelexGLM differentiates androgen and glucocorticoid receptor DNA-binding preference over an extended binding site
por: Zhang, Liyang, et al.
Publicado: (2018)

Optimisation of TP53 reporters by systematic dissection of synthetic TP53 response elements
por: Trauernicht, Max, et al.
Publicado: (2023)

Identifying genetic regulatory variants that affect transcription factor activity
por: Li, Xiaoting, et al.
Publicado: (2023)

Systematic in vitro profiling of off-target affinity, cleavage and efficiency for CRISPR enzymes
por: Zhang, Liyang, et al.
Publicado: (2020)

TransfactomeDB: a resource for exploring the nucleotide sequence specificity and condition-specific regulatory activity of trans-acting factors
por: Foat, Barrett C., et al.
Publicado: (2008)

Evolving insights on how cytosine methylation affects protein–DNA binding
por: Dantas Machado, Ana Carolina, et al.
Publicado: (2015)

Modeling gene expression control using Omes Law
por: Bussemaker, Harmen J
Publicado: (2006)

The human HOXA9 protein uses paralog-specific residues of the homeodomain to interact with TALE-class cofactors
por: Dard, Amélie, et al.
Publicado: (2019)

Building accurate sequence-to-affinity models from high-throughput in vitro protein-DNA binding data using FeatureREDUCE
por: Riley, Todd R, et al.
Publicado: (2015)

Identifying the genetic determinants of transcription factor activity
por: Lee, Eunjee, et al.
Publicado: (2010)

Histone Chaperone Paralogs Have Redundant, Cooperative, and Divergent Functions in Yeast
por: Savic, Neda, et al.
Publicado: (2019)

MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer
por: Dammert, Marcel A., et al.
Publicado: (2019)

Predicting functional transcription factor binding through alignment-free and affinity-based analysis of orthologous promoter sequences
por: Ward, Lucas D., et al.
Publicado: (2008)

Alternative Functional rad21 Paralogs in Fusarium oxysporum
por: Pareek, Manish, et al.
Publicado: (2019)

Harnessing Natural Sequence Variation to Dissect Posttranscriptional Regulatory Networks in Yeast
por: Fazlollahi, Mina, et al.
Publicado: (2014)

The role of structural pleiotropy and regulatory evolution in the retention of heteromers of paralogs
por: Marchant, Axelle, et al.
Publicado: (2019)

Assessing constraints on the path of regulatory sequence evolution
por: Glassford, William J., et al.
Publicado: (2013)

Two paralogous EcfG σ factors hierarchically orchestrate the activation of the General Stress Response in Sphingopyxis granuli TFA
por: de Dios, Rubén, et al.
Publicado: (2020)

Dissecting complex transcriptional responses using pathway-level scores based on prior information
por: Bussemaker, Harmen J, et al.
Publicado: (2007)

Defining transcriptional networks through integrative modeling of mRNA expression and transcription factor binding data
por: Gao, Feng, et al.
Publicado: (2004)

Characterizing a collective and dynamic component of chromatin immunoprecipitation enrichment profiles in yeast
por: Ward, Lucas D, et al.
Publicado: (2014)

DAF-16 and PQM-1: Partners in longevity
por: Tepper, Ronald G., et al.
Publicado: (2014)

A transcriptional cofactor regulatory network for the C. elegans intestine
por: Horowitz, Brent B, et al.
Publicado: (2023)

Systematic prediction of DNA shape changes due to CpG methylation explains epigenetic effects on protein–DNA binding
por: Rao, Satyanarayan, et al.
Publicado: (2018)

Esc2 orchestrates substrate-specific sumoylation by acting as a SUMO E2 cofactor in genome maintenance
por: Li, Shibai, et al.
Publicado: (2021)

Duplicated ribosomal protein paralogs promote alternative translation and drug resistance
por: Malik Ghulam, Mustafa, et al.
Publicado: (2022)

The RNA backbone plays a crucial role in mediating the intrinsic stability of the GpU dinucleotide platform and the GpUpA/GpA miniduplex
por: Lu, Xiang-Jun, et al.
Publicado: (2010)

DSSR: an integrated software tool for dissecting the spatial structure of RNA
por: Lu, Xiang-Jun, et al.
Publicado: (2015)

Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling
por: Hartl, Frederike A., et al.
Publicado: (2021)

The NuRD complex cooperates with SALL4 to orchestrate reprogramming
por: Wang, Bo, et al.
Publicado: (2023)

Chromatin Environment and Cellular Context Specify Compensatory Activity of Paralogous MEF2 Transcription Factors
por: Majidi, Shahriyar P., et al.
Publicado: (2019)

Rodent-specific alternative exons are more frequent in rapidly evolving genes and in paralogs
por: Nurtdinov, Ramil N, et al.
Publicado: (2009)

Low potential enzymatic hydride transfer via highly cooperative and inversely functionalized flavin cofactors
por: Willistein, Max, et al.
Publicado: (2019)

Antagonism Versus Cooperativity with TALE Cofactors at the Base of the Functional Diversification of Hox Protein Function
por: Rivas, María Luisa, et al.
Publicado: (2013)

B(12) cofactors directly stabilize an mRNA regulatory switch
por: Johnson, James E., et al.
Publicado: (2012)

Context Drives Diversification of Monocytes and Neutrophils in Orchestrating the Tumor Microenvironment
por: Jeong, Juhee, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ppac30ruuihes4hs1mo5tqlbh4