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Stably Integrating an Inducible CRISPR-Cas9 to Protect Against Viral Infections in Vitro

CRISPR-Cas systems protect bacteria from viral nucleic acids. The Cas9 enzyme cleaves bacteriophage DNA preventing viral genes from being expressed in the bacterial host. In this work, the Cas9 protein is repurposed to function as an intracellular mammalian defense mechanism that protects human cell...

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Detalles Bibliográficos
Autores principales: Madireddy, Indeever, Pierson Smela, Merrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250034/
https://www.ncbi.nlm.nih.gov/pubmed/35789697
http://dx.doi.org/10.17912/micropub.biology.000590