Endosomal LC3C-pathway selectively targets plasma membrane cargo for autophagic degradation

Autophagy selectively targets cargo for degradation, yet mechanistic understanding remains incomplete. The ATG8-family plays key roles in autophagic cargo recruitment. Here by mapping the proximal interactome of ATG8-paralogs, LC3B and LC3C, we uncover a LC3C-Endocytic-Associated-Pathway (LEAP) that...

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Detalles Bibliográficos
Autores principales: Coelho, Paula P., Hesketh, Geoffrey G., Pedersen, Annika, Kuzmin, Elena, Fortier, Anne-Marie N., Bell, Emily S., Ratcliffe, Colin D. H., Gingras, Anne-Claude, Park, Morag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250516/
https://www.ncbi.nlm.nih.gov/pubmed/35780247
http://dx.doi.org/10.1038/s41467-022-31465-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250516/
https://www.ncbi.nlm.nih.gov/pubmed/35780247
http://dx.doi.org/10.1038/s41467-022-31465-3

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