LIN28B inhibition sensitizes cells to p53-restoring PPI therapy through unleashed translational suppression

p53 is the most highly mutated tumor suppressor across multiple types of human cancers. The level and function of p53 are fine-tuned through multifaced mechanisms in which the protein–protein interaction between p53 and MDM2 is considered as a major circuit. Recent studies suggest therapeutic strate...

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Detalles Bibliográficos
Autores principales: Shi, Jiahao, Jin, Xiaoliang, Wang, Yihao, Zhu, Tianyu, Zhang, Dongmei, Li, Qian, Zhong, Xiaomin, Deng, Yaqi, Shen, Jianfeng, Fan, Xianqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250532/
https://www.ncbi.nlm.nih.gov/pubmed/35780125
http://dx.doi.org/10.1038/s41389-022-00412-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250532/
https://www.ncbi.nlm.nih.gov/pubmed/35780125
http://dx.doi.org/10.1038/s41389-022-00412-8

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