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LIN28B inhibition sensitizes cells to p53-restoring PPI therapy through unleashed translational suppression
p53 is the most highly mutated tumor suppressor across multiple types of human cancers. The level and function of p53 are fine-tuned through multifaced mechanisms in which the protein–protein interaction between p53 and MDM2 is considered as a major circuit. Recent studies suggest therapeutic strate...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250532/ https://www.ncbi.nlm.nih.gov/pubmed/35780125 http://dx.doi.org/10.1038/s41389-022-00412-8 |