Single-molecule FRET uncovers hidden conformations and dynamics of human Argonaute 2

Human Argonaute 2 (hAgo2) constitutes the functional core of the RNA interference pathway. Guide RNAs direct hAgo2 to target mRNAs, which ultimately leads to hAgo2-mediated mRNA degradation or translational inhibition. Here, we combine site-specifically labeled hAgo2 with time-resolved single-molecu...

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Detalles Bibliográficos
Autores principales: Willkomm, Sarah, Jakob, Leonhard, Kramm, Kevin, Graus, Veronika, Neumeier, Julia, Meister, Gunter, Grohmann, Dina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250533/
https://www.ncbi.nlm.nih.gov/pubmed/35780145
http://dx.doi.org/10.1038/s41467-022-31480-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250533/
https://www.ncbi.nlm.nih.gov/pubmed/35780145
http://dx.doi.org/10.1038/s41467-022-31480-4

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