Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale

Macrocycles have excellent potential as therapeutics due to their ability to bind challenging targets. However, generating macrocycles against new targets is hindered by a lack of large macrocycle libraries for high-throughput screening. To overcome this, we herein established a combinatorial approa...

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Detalles Bibliográficos
Autores principales: Habeshian, Sevan, Merz, Manuel Leonardo, Sangouard, Gontran, Mothukuri, Ganesh Kumar, Schüttel, Mischa, Bognár, Zsolt, Díaz-Perlas, Cristina, Vesin, Jonathan, Bortoli Chapalay, Julien, Turcatti, Gerardo, Cendron, Laura, Angelini, Alessandro, Heinis, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250534/
https://www.ncbi.nlm.nih.gov/pubmed/35780129
http://dx.doi.org/10.1038/s41467-022-31428-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250534/
https://www.ncbi.nlm.nih.gov/pubmed/35780129
http://dx.doi.org/10.1038/s41467-022-31428-8

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