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Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale
Macrocycles have excellent potential as therapeutics due to their ability to bind challenging targets. However, generating macrocycles against new targets is hindered by a lack of large macrocycle libraries for high-throughput screening. To overcome this, we herein established a combinatorial approa...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250534/ https://www.ncbi.nlm.nih.gov/pubmed/35780129 http://dx.doi.org/10.1038/s41467-022-31428-8 |