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The role of lipid components in lipid nanoparticles for vaccines and gene therapy

Lipid nanoparticles (LNPs) play an important role in mRNA vaccines against COVID-19. In addition, many preclinical and clinical studies, including the siRNA-LNP product, Onpattro®, highlight that LNPs unlock the potential of nucleic acid-based therapies and vaccines. To understand what is key to the...

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Detalles Bibliográficos
Autores principales: Hald Albertsen, Camilla, Kulkarni, Jayesh A., Witzigmann, Dominik, Lind, Marianne, Petersson, Karsten, Simonsen, Jens B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250827/
https://www.ncbi.nlm.nih.gov/pubmed/35787388
http://dx.doi.org/10.1016/j.addr.2022.114416